The Highlander Limited's optional pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The QX50 doesn't offer pre-crash pretensioners.
When descending a steep, off-road slope, the Highlander AWD's standard Downhill Assist Control allows you to creep down safely. The QX50 doesn't offer Downhill Assist Control.
To help make backing safer, the Highlander Limited/Platinum's cross-path warning system uses wide-angle radar in the rear bumper to alert the driver to vehicles approaching from the side, helping the driver avoid collisions. The QX50 doesn't offer a cross-path warning system.
The Highlander Limited offers optional Safety Connect™, which uses a global positioning satellite (GPS) receiver and a cellular system to help track down your vehicle if it's stolen or send emergency personnel to the scene if any airbags deploy. The QX50 doesn't offer a GPS response system, only a navigation computer with no live response for emergencies, so if you're involved in an accident and you're incapacitated help may not come as quickly.
Both the Highlander and the QX50 have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, daytime running lights, rearview cameras, available crash mitigating brakes, lane departure warning systems, blind spot warning systems and rear parking sensors.
For its top level performance in all IIHS frontal, side, rear impact and roof-crush tests, and with its optional front crash prevention system, the Insurance Institute for Highway Safety grants the Highlander its highest rating: “Top Pick Plus” for 2016, a rating granted to only 73 vehicles tested by the IIHS. The QX50 has not been tested, yet.

